Infertility Treatment For Women Suggested By Mouse Study

A discovery in mice of immune cells that promote the formation of new blood vessels could lead to new treatments for endometriosis, a painful condition associated with infertility that affects up to 15 percent of women of reproductive age. The new research in vascular biology may point the way to treating endometriosis nonsurgically — by inhibiting angiogenesis (new blood vessel growth) so that lesions remain small and harmless.
Continue reading “Infertility Treatment For Women Suggested By Mouse Study”

Advertisements

Zinc may reduce pneumonia risk in nursing home elderly

When elderly nursing home residents contract pneumonia, it is a blow to their already fragile health. Simin Nikbin Meydani, DVM, PhD of the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University and colleagues report that maintaining normal serum zinc concentration in the blood may help reduce the risk of pneumonia development in that population.

Continue reading “Zinc may reduce pneumonia risk in nursing home elderly”

Deficiency of immune system ‘peacekeeper’ pinpointed in mice as cause of ulcerative colitis

n a series of mouse experiments, researchers at the Harvard School of Public Health (HSPH) have pinpointed a specific immune deficiency as the likely fundamental cause of ulcerative colitis, a chronic, sometimes severe inflammatory disease of the colon or large intestine that afflicts half a million Americans. Remarkably, the researchers also found that once the disease was established in mice, it could be passed from mother to offspring and even between adult animals, with potential implications for public health and prevention.

The researchers have linked ulcerative colitis in mice to a deficiency of a molecular “peacekeeper” in the immune system, allowing harmful bacteria in the large intestine to breach the bowel’s protective lining and trigger damaging inflammation.

Continue reading “Deficiency of immune system ‘peacekeeper’ pinpointed in mice as cause of ulcerative colitis”

New technique to ‘see’ and protect transplants successful in diabetic animal model

Researchers at Johns Hopkins have found a way to overcome a major stumbling block to developing successful insulin-cell transplants for people with type I diabetes.

Traditional transplant of the cells, accompanied by necessary immune-suppressing drugs, has had highly variable results, from well- to poorly tolerated. Part of the problem, the Hopkins researchers say, is an inability to track the cells—so-called pancreatic beta cells—once they’re inside the body.

Now a new technique encapsulates the insulin-producing cells in magnetic capsules, using an FDA-approved iron compound with an off-label use, which can be tracked by magnetic resonance imaging (MRI). The product, tested in swine and diabetic mice, also simultaneously avoids rejection by the immune system, likely a major reason for transplant failure. The work will be published online next week in Nature Medicine.

Continue reading “New technique to ‘see’ and protect transplants successful in diabetic animal model”

Risk genes for multiple sclerosis uncovered

A large-scale genomic study has uncovered new genetic variations associated with multiple sclerosis (MS), findings that suggest a possible link between MS and other autoimmune diseases. The study, led by an international consortium of clinical scientists and genomics experts, is the first comprehensive study investigating the genetic basis of MS. Findings appear in the July 29 online edition of the New England Journal of Medicine.

Continue reading “Risk genes for multiple sclerosis uncovered”

White blood cells are picky about sugar

Biology textbooks are blunt—neutrophils are mindless killers. These white blood cells patrol the body and guard against infection by bacteria and fungi, identifying and destroying any invaders that cross their path. But new evidence, which may lead to better drugs to fight deadly pathogens, indicates that neutrophils might actually distinguish among their targets.

Continue reading “White blood cells are picky about sugar”

Virus Uses Tiny RNA To Evade The Immune System

In the latest version of the hide-and-seek game between pathogens and the hosts they infect, researchers have found that a virus appears to cloak itself with a recently discovered gene silencing device to evade detection and destruction by immune cells.

The report by Howard Hughes Medical Institute (HHMI) researchers in an article published in the June 2, 2005, issue of Nature may be the first to show how a virus uses the gene silencing machinery for its own infectious purposes.

Continue reading “Virus Uses Tiny RNA To Evade The Immune System”