A new brake on cellular energy production discovered

A condition that has to be met for the body to be able to keep warm, move and even survive is that the mitochondria – the cells’ power stations – release the right amounts of energy. Scientists at Karolinska Institutet have now identified the first known factor that acts as a brake on cellular energy production.

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Obesity May Be Associated With A Relative Of Anti-aging Gene, Klotho

A relative of the anti-aging gene Klotho helps activate a hormone that can lower blood glucose levels in fat cells of mice, making it a novel target for developing drugs to treat human obesity and diabetes, UT Southwestern Medical Center researchers have found.

Dr. Makoto Kuro-o, associate professor of pathology, has reported that a relative of the anti-aging gene Klotho helps activate a hormone that can lower blood glucose levels in fat cells of mice. This discovery of a particular type of Klotho protein could eventually make it a novel target for developing drugs to treat human obesity and diabetes.
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How Eating Less Might Make You Live Longer

Caloric Restriction in non-obese people translates into less oxidative damage in muscle cells, according to a new study by scientists at Pennington Biomedical Research Center. As oxidative damage has been linked to aging, this could explain how limiting calorie intake without malnutrition extends life span.

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Civitarese and colleagues found that indeed fewer calories can improve whole body metabolism in conjunction with an increase in SIRT1 gene expression in skeletal muscle. These results raise the possibility that SIRT1 may contribute to more efficient metabolism, less oxidative stress, and increase longevity in humans as it does in lower organism. (Credit: Image courtesy of Public Library of Science)
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