New hope for multiple sclerosis sufferers

A drug which was developed in Cambridge and initially designed to treat a form of leukaemia has also proven effective against combating the debilitating neurological disease multiple sclerosis (MS).

The study, led by researchers from the University of Cambridge, has found that alemtuzumab not only stops MS from advancing in patients with early stage active relapsing-remitting multiple sclerosis (RRMS) but may also restore lost function caused by the disease. The findings were published today in the New England Journal of Medicine. Continue reading “New hope for multiple sclerosis sufferers”

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How eating fruit and vegetables can improve cancer patients’ response to chemotherapy

The leading cause of death in all cancer patients continues to be the resistance of tumor cells to chemotherapy, a form of treatment in which chemicals are used to kill cells.

Now a study by UC Riverside biochemists that focuses on cancer cells reports that ingesting apigenin – a naturally occurring dietary agent found in vegetables and fruit – improves cancer cells’ response to chemotherapy. Continue reading “How eating fruit and vegetables can improve cancer patients’ response to chemotherapy”

Scientists find potential strategy to eliminate poisonous protein from Alzheimer brains

Scientists at the Gladstone Institute of Neurological Disease (GIND) have identified a new strategy to destroy amyloid-beta (AB) proteins, which are widely believed to cause Alzheimer’s disease (AD). Li Gan, PhD, and her coworkers discovered that the activity of a potent AB-degrading enzyme can be unleashed in mouse models of the disease by reducing its natural inhibitor cystatin C (CysC). Continue reading “Scientists find potential strategy to eliminate poisonous protein from Alzheimer brains”

Research uncovers new steps on pathway to enlarged heart

Researchers have new insight into the mechanisms that underlie a pathological increase in the size of the heart. The research, published by Cell Press in the October 24th issue of the journal Molecular Cell, may lead to the development of new strategies for managing this extremely common cardiac ailment that often leads to heart failure. Continue reading “Research uncovers new steps on pathway to enlarged heart”

Chemists devise self-assembling ‘organic wires’

From pacemakers constructed of materials that so closely mimic human tissues that a patient’s body can’t discern the difference to devices that bypass injured spinal cords to restore movement to paralyzed limbs, the possibilities presented by organic electronics read like something from a science fiction novel.

Derived from carbon-based compounds (hence the term “organic”), these “soft” electronic materials are valued as lightweight, flexible, easily processed alternatives to “hard” electronics components such as metal wires or silicon semiconductors. And just as the semiconductor industry is actively developing smaller and smaller transistors, so, too, are those involved with organic electronics devising ways to shrink the features of their materials, so they can be better utilized in bioelectronic applications such as those above. Continue reading “Chemists devise self-assembling ‘organic wires’”

Green tea may delay onset of type 1 diabetes

A powerful antioxidant in green tea may prevent or delay the onset of type 1 diabetes, Medical College of Georgia researchers say.

Researchers were testing EGCG, green tea’s predominant antioxidant, in a laboratory mouse with type 1 diabetes and primary Sjogren’s syndrome, which damages moisture-producing glands, causing dry mouth and eyes. Continue reading “Green tea may delay onset of type 1 diabetes”

Gene therapy restores vision to mice with retinal degeneration

Massachusetts General Hospital (MGH) researchers have used gene therapy to restore useful vision to mice with degeneration of the light-sensing retinal rods and cones, a common cause of human blindness. Their report, appearing in the Oct. 14 Proceedings of the National Academy of Sciences, describes the effects of broadly expressing a light-sensitive protein in other neuronal cells found throughout the retina. Continue reading “Gene therapy restores vision to mice with retinal degeneration”