Exercise, calorie restrictions can rejuvenate older synapses

Harvard researchers have uncovered a mechanism in mice through which caloric restriction and exercise delay some of the debilitating effects of aging by rejuvenating the connections between nerves and the muscles that they control.

The research, published online by the journal Proceedings of the National Academy of Sciences, was conducted in the labs of Joshua Sanes and Jeff Lichtman, both members of the Center for Brain Science at Harvard and professors of molecular and cellular biology.  Their findings begin to explain prior findings that exercise and restricted-calorie diets help to stave off the mental and physical degeneration of aging.
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