Genes that protect against atherosclerosis identified

One way of combating atherosclerosis is to reduce levels of “bad cholesterol” in the blood. Scientists at the Swedish medical university Karolinska Institutet have now identified the genes that bring about this beneficial effect.

Continue reading “Genes that protect against atherosclerosis identified”

The missing link between belly fat and heart disease?

By now, everyone knows that overweight people have a higher risk of heart attacks, strokes and other problems that arise from clogged, hardened arteries. And people who carry their extra weight around their waist – giving them a “beer belly” or an “apple” shape — have the highest risk of all.But despite the impact on human health, the reasons behind this connection between heart disease and belly fat – also known as visceral fat — have eluded scientists. Now, a new study in mice gives the first direct evidence of why this link might exist – and a tantalizing look at how it might be broken.
Continue reading “The missing link between belly fat and heart disease?”

Lipoic acid could reduce atherosclerosis, weight gain

A new study done with mice has discovered that supplements of lipoic acid can inhibit formation of arterial lesions, lower triglycerides, and reduce blood vessel inflammation and weight gain – all key issues for addressing cardiovascular disease.

Although the results cannot be directly extrapolated beyond the laboratory, researchers report that “they strongly suggest that lipoic acid supplementation may be useful as an inexpensive but effective intervention strategy . . . reducing known risk factors for the development of atherosclerosis and other inflammatory vascular diseases in humans.”

Continue reading “Lipoic acid could reduce atherosclerosis, weight gain”

Eating your greens could prove life-saving if a heart attack strikes

A diet rich in leafy vegetables may minimize the tissue damage caused by heart attacks, according to researchers at the Albert Einstein College of Medicine of Yeshiva University. Their findings, published in the November 12 Proceedings of the National Academy of Sciences, suggest that the chemical nitrite, found in many vegetables, could be the secret ingredient in the heart-healthy Mediterranean diet.

Continue reading “Eating your greens could prove life-saving if a heart attack strikes”

Researchers discover novel pathway for increasing ‘good’ cholesterol

Researchers at the University of Pennsylvania School of Medicine have discovered that a group of liver enzymes called proprotein convertases (PCs) may be the key to raising levels of good cholesterol (HDL-C). The pathway by which these proteins are able to achieve an increase in HDL cholesterol involves another enzyme that normally degrades HDL-C, and was also discovered at Penn. The newly recognized relationship between these enzymes and cholesterol represents another target for ultimately controlling good cholesterol.

Continue reading “Researchers discover novel pathway for increasing ‘good’ cholesterol”

It’s not too late to change and lower cardiac risk later in life

Can adopting a healthier lifestyle later in life help — or is it too late? In a study published in the July 2007 issue of The American Journal of Medicine, researchers from the Medical University of South Carolina, Charleston found that people 45 to 64 years of age who added healthy lifestyle behaviors could substantially reduce their risk for cardiovascular disease (CVD) and reduce their death rate. Once these people achieved 4 healthy behaviors, eating at least 5 fruits and vegetables daily, exercising at least 2.5 hours per week, maintaining their Body Mass Index (BMI) between 18.5 and 30 kg/m, and not smoking, investigators saw a 35% reduction in CVD incidence and a 40% reduction in mortality compared to people with less healthy lifestyles.

Continue reading “It’s not too late to change and lower cardiac risk later in life”

Precursor Cells Generated From Human Embryonic Stem Cells Show Ability to Repair Vascular Damage

Scientists reported for the first time that hemangioblast precursor cells derived from human embryonic stem (hES) cells can be used to achieve vascular repair.

The research, which appears today online (ahead of print) in the journal Nature Methods, by Advanced Cell Technology (ACT) and its collaborators, describes an efficient method for generating large numbers of bipotential progenitors–known as hemangioblasts–from hES cells that are capable of differentiating into blood vessels, as well as into all blood and immune cell lineages.
Continue reading “Precursor Cells Generated From Human Embryonic Stem Cells Show Ability to Repair Vascular Damage”

Cholesterol-lowering Drugs Reduce Risk Of Stroke, Heart Attack

People whose cholesterol improved after one month on cholesterol-lowering drugs called statins reduced their risk of stroke and heart attack, according to research presented at the American Academy of Neurology’s 59th Annual Meeting in Boston, April 28 — May 5, 2007.
Continue reading “Cholesterol-lowering Drugs Reduce Risk Of Stroke, Heart Attack”

A steady, high-fat diet is bad, but the news gets worse

So much for the adage, ‘All things in moderation.’ Researchers at the University of Calgary have found that people who consume a single, high-fat meal are more prone to suffer the physical consequences of stress than those who eat a low-fat meal.
Continue reading “A steady, high-fat diet is bad, but the news gets worse”

Link found between immune system and high plasma lipid levels

Researchers at the University of Chicago have found an unsuspected link between the immune system and high plasma lipid levels (cholesterol and triglycerides in the blood) in mice. The finding could lead to new ways to reduce the risk of heart disease by lowering elevated lipid levels.
Continue reading “Link found between immune system and high plasma lipid levels”

Despite significantly raising HDL, torcetrapib failed to slow the progression of coronary plaques

Investigators reported today that torcetrapib, a drug that substantially raises high-density lipoprotein cholesterol or HDL (the “good” cholesterol), did not slow the progression of plaque buildup in the coronary arteries as measured using an ultrasound probe (IVUS). All development of this drug was terminated on December 2, 2006 after the safety board monitoring a separate large clinical outcomes trial reported that torcetrapib increased the risk of death and other adverse cardiovascular outcomes.
Continue reading “Despite significantly raising HDL, torcetrapib failed to slow the progression of coronary plaques”

Researchers find only vegetarian low-carb diet is associated with lower risk of heart disease

Advocates of low-carbohydrate diets, such as the popular Atkins diet, claim that those diets may help prevent obesity and coronary heart disease (CHD). However, the long-term safety of those diets has been debated, particularly because they encourage the consumption of animal products, which are high in saturated fats and cholesterol and could potentially increase the risk of CHD. Prevailing dietary recommendations have advocated a contrary approach, recommending diets that are low in fat and high in carbohydrates as the best way to manage weight and reduce the risk of cardiovascular disease.

In the first study to look at the long-term effects of low-carbohydrate diets, researchers from the Harvard School of Public Health (HSPH) found no evidence of an association between low-carb diets and an increased risk of CHD in women. Their findings did suggest, however, an association between low-carb diets high in vegetable sources of fat and protein and a low risk of CHD.
Continue reading “Researchers find only vegetarian low-carb diet is associated with lower risk of heart disease”

Researchers demonstrate ability of new therapy to treat severely elevated cholesterol levels

Researchers at the University of Pennsylvania School of Medicine have demonstrated the potential of a new type of therapy for patients who suffer from high cholesterol levels. The findings are in the January 11 issue of the New England Journal of Medicine (NEJM). In this study, patients with homozygous familial hypercholesterolemia (FH), a high-risk condition refractory to conventional therapy, had a remarkable 51% reduction in low-density lipoprotein (LDL) or “bad cholesterol” levels.
2845_web.jpg
Continue reading “Researchers demonstrate ability of new therapy to treat severely elevated cholesterol levels”

Link identified between age, cardiovascular disease

Researchers in the Linus Pauling Institute at Oregon State University have discovered a fundamental mechanism that causes aging blood vessels to lose their elasticity – a literal “hardening of the arteries” that is often a prelude to high blood pressure and cardiovascular disease.

An understanding of this mechanism, scientists say, provides an important new target for both drugs and dietary changes that might help prevent or treat atherosclerosis and heart disease. This is a leading cause of death around the world that, in some form, affects about 80 percent of older Americans.
Continue reading “Link identified between age, cardiovascular disease”

Scientists find boosting protein levels staves off heart failure

Boosting levels of a protein in the heart might help protect against the development of heart failure, particularly in those who have had heart attacks.

Cardiology researchers at the Center for Translational Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia found that increasing levels of the protein S100A1 above normal helped protect animal hearts from further damage after simulated heart attacks. In some cases, the animals’ heart function hardly changed at all. At the same time, other animals with heart cells lacking the gene for the protein couldn’t handle the stress of a heart blockage; they went on to develop heart failure.
Continue reading “Scientists find boosting protein levels staves off heart failure”

Alpha-lipoic acid completely prevents atherosclerosis in mice

An article published in the August, 2006 issue of the American Diabetes Association journal Diabetes reported the findings of Xianwen Yi and Nobuyo Maeda of the University of North Carolina at Chapel Hill that giving alpha-lipoic acid to mice in whom diabetes was induced prevented the increase in cholesterol, atherosclerotic lesions and health deterioration that the disease would otherwise cause. Alpha-lipoic acid is a potent antioxidant nutrient that has been used to treat diabetic neuropathy, however, its effects in diabetic cardiovascular disease have not been completely evaluated.

Continue reading “Alpha-lipoic acid completely prevents atherosclerosis in mice”