A genetic study of more than 90,000 people has identified six new genetic variants that are associated with increased Body Mass Index (BMI), the most commonly used measure of obesity. Five of the genes are known to be active in the brain, suggesting that many genetic variants implicated in obesity might affect behaviour, rather than the chemical processes of energy or fat metabolism.
By now, everyone knows that overweight people have a higher risk of heart attacks, strokes and other problems that arise from clogged, hardened arteries. And people who carry their extra weight around their waist – giving them a “beer belly” or an “apple” shape — have the highest risk of all.But despite the impact on human health, the reasons behind this connection between heart disease and belly fat – also known as visceral fat — have eluded scientists. Now, a new study in mice gives the first direct evidence of why this link might exist – and a tantalizing look at how it might be broken.
Continue reading “The missing link between belly fat and heart disease?”
Scientists in Taiwan are reporting new insights into why diets rich in fruits and vegetables reduce the risk of obesity. Their study focuses on healthful natural antioxidant compounds called flavonoids and phenolic acids. Continue reading “New Insights Into How Natural Antioxidants Fight Fat”
Researchers at UT Southwestern Medical Center have found that a single gene might control whether or not individuals tend to pile on fat, a discovery that may point to new ways to fight obesity and diabetes.
“From worms to mammals, this gene controls fat formation,” said Dr. Jonathan Graff, associate professor of developmental biology and internal medicine at UT Southwestern and senior author of a study appearing in the Sept. 5 issue of Cell Metabolism. “It could explain why so many people struggle to lose weight and suggests an entirely new direction for developing medical treatments that address the current epidemic of diabetes and obesity.
“People who want to fit in their jeans might someday be able to overcome their genes.”
Continue reading “Researchers discover a gene that might control fat accumulation”
An extensive swedish study from the Sahlgrenska Academy has established that surgery reduces premature death in patients with severe obesity. A long-term follow up has shown that mortality is significantly lower among patients who undergo surgery than among those who do not.
Colon cancer patients who eat a diet high in red meat, fatty products, refined grains, and desserts — a so-called “Western diet” — may be increasing their chance of disease relapse and early death, report researchers at Dana-Farber Cancer Institute.
A new Joslin Diabetes Center-led study has identified a protein found in fat cells that may play a major role in how fat is produced and stored, offering a new target for treatments to prevent obesity and reduce the risk for type 2 diabetes. This latest research appears in the August 2007 issue of Cell Metabolism.
Part of an ongoing study into the impact of drinking milk after heavy weightlifting has found that milk helps exercisers burn more fat.
Taking a break in the middle of your workout may metabolize more fat than exercising without stopping, according to a recent study in Japan. Researchers conducted the first known study to compare these two exercise methods—exercising continually in one long bout versus breaking up the same workout with a rest period. The findings could change the way we approach exercise. Who wouldn’t want to take a breather for that”
Abdominal fat, the spare tire that many of us carry, has long been implicated as a primary suspect in causing the metabolic syndrome, a cluster of conditions that includes the most dangerous heart attack risk factors: prediabetes, diabetes, high blood pressure, and changes in cholesterol.
But with the help of powerful new imaging technologies, a team of Howard Hughes Medical Institute (HHMI) researchers at Yale University School of Medicine has found that insulin resistance in skeletal muscle leads to alterations in energy storage that set the stage for the metabolic syndrome.
Researchers at Dana-Farber Cancer Institute have identified a long-sought “master switch” in mice for the production of brown fat, a type of adipose tissue that generates heat and counters obesity caused by overeating.
A team headed by Bruce Spiegelman, PhD, suggests in the July issue of Cell Metabolism that turning up the equivalent switch in people might be a new strategy for treating overweight and obesity. The investigators said their next step is to rev up the control in mice and overfeed them to see if they are resistant to becoming obese.
A search for the molecular clues of longevity has taken Mayo Clinic researchers down another path that could explain why some people who consume excessive calories don’t gain weight. The study, which was done in laboratory mouse models, points to the absence of a gene called CD38. When absent, the gene prevented mice on high-fat diets from gaining weight, but when present, the mice became obese.
Facing a July 1 deadline, most restaurants have already eliminated artificial trans fat in oils used for frying, a new Health Department survey shows. The agency reported today that 83% of restaurants were not using artificial trans fat for frying as of June 1 – a full month before the new regulation will take effect
In what they call a “stunning research advance,” investigators at Georgetown University Medical Center have been able to use simple, non-toxic chemical injections to add and remove fat in targeted areas on the bodies of laboratory animals. They say the discovery, published online in Nature Medicine on July 1, could revolutionize human cosmetic and reconstructive plastic surgery and treatment of diseases associated with human obesity.