Scientists identify new longevity genes

Scientists at the University of Washington and other institutions have identified 25 genes regulating lifespan in two organisms separated by about 1.5 billion years in evolutionary change. At least 15 of those genes have very similar versions in humans, suggesting that scientists may be able to target those genes to help slow down the aging process and treat age-related conditions.

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Aging gracefully requires taking out the trash

Suppressing a cellular cleanup-mechanism known as autophagy can accelerate the accumulation of protein aggregates that leads to neural degeneration. In an upcoming issue of Autophagy, scientists at the Salk Institute for Biological Studies report for the first time that the opposite is true as well: Boosting autophagy in the nervous system of fruit flies prevented the age-dependent accumulation of cellular damage in neurons and promoted longevity.

 

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10-fold life span extension reported in simple organism

Biologists have created baker’s yeast capable of living to 800 in yeast years without apparent side effects. The basic but important discovery, achieved through a combination of dietary and genetic changes, brings science closer to controlling the survival and health of the unit of all living systems: the cell.
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4 health behaviors can add 14 extra years of life

People who adopt four healthy behaviours – not smoking; taking exercise; moderate alcohol intake; and eating five servings of fruit and vegetables a day – live on average an additional fourteen years of life compared with people who adopt none of these behaviours, according to a study published in the open access journal PLoS Medicine.

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Wake up and smell the coffee

A forthcoming article in the British Journal of Nutrition, published online on December 6, 2007, reported the finding of Finnish researchers that an increased intake of coffee is associated with lower mortality over a 14.5 year period.

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A longer-living, healthier mouse that could hold clues to human aging

A study by scientists at UCL (University College London) shows that mice lacking the insulin receptor substrate (IRS)-1 are more resistant to ageing than normal mice. The research adds to a growing body of work showing the importance of insulin signalling pathways as an ageing mechanism in mammals – and potentially humans.

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Scientists link gene that promotes long lifespan to cholesterol

MIT researchers have discovered a link between a gene believed to promote long lifespan and a pathway that flushes cholesterol from the body.

The finding could help researchers create drugs that lower the risk of diseases associated with high cholesterol, including atherosclerosis (clogged arteries) and Alzheimer’s disease.

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