Computer model reveals cells’ inner workings

After spending years developing a computational model to help illuminate cell signaling pathways, a team of MIT researchers decided to see what would happen if they “broke” the model.

The results, reported in the Oct. 17 issue of the journal Cell, reveal new ways in which cells process chemical information and could indicate how to maximize the effectiveness of disease treatments such as chemotherapy. Continue reading “Computer model reveals cells’ inner workings”

Could Dr. House be replaced by a computer?

Scientists know that different normal and diseased tissues behave differently. But a method that tells them just how they do so may one day give medical science a new way to fight obesity, hypertension, diabetes and other dangerous disorders of the metabolism.

Until now, scientists had to rely on basic observations at the cellular level, since they lacked information about the metabolic processes of individual organs, such as the liver, heart and brain.

But a new computational approach developed by computer scientists Tomer Shlomi, Moran Cabili and Prof. Eytan Ruppin from the Blavatnik School of Computer Science at Tel Aviv University may help science gain a clearer overall picture of the metabolic processes in our different tissues. Continue reading “Could Dr. House be replaced by a computer?”

Biology enters ‘The Matrix’ through new computer language

Ever since the human genome was sequenced less than 10 years ago, researchers have been able to access a dizzying plethora of genomic information with a simple click of a mouse. This digitizing of genomic data—and its public access—is something that would have been unthinkable a generation earlier.
Continue reading “Biology enters ‘The Matrix’ through new computer language”