Mice with human livers deal with drugs the human way

The unique physiology of the human liver means that the toxicity of some candidate drugs is not picked up during preclinical tests in animals. But mice implanted with miniature human livers can mimic the ways in which the human body breaks down chemical compounds, to help spot potential problems before drugs are tested in humans.

A team led by Sangeeta Bhatia, a biomedical engineer at the Massachusetts Institute of Technology in Cambridge, made 20-millimetre-long artificial human livers and implanted them into otherwise normal mice. The researchers report today in Proceedings of the National Academy of Sciences1, that the mice showed metabolism characteristic of the human liver for weeks after implantation.

via Mice with human livers deal with drugs the human way : Nature News.

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