Ellen Goode and her colleagues at the Mayo Clinic found a surprise while studying the human genome: four chromosomal locations with mutations that could lead to an increased risk of ovarian cancer. But the biggest surprise was a number of SNPs on chromosome 8 that seem to act through a different mechanism than other polymorphisms to influence cancer risk. Genome Technology’s Christie Rizk spoke with Goode about her study, which appeared in Nature Genetics in October.