Scientists Discover a Gene That Regulates Lifespan

Genes that control the timing of organ formation during development also control timing of aging and death, and provide evidence of a biological timing mechanism for aging, Yale researchers report in the journal Science.

“Although there is a large variation in lifespan from species to species, there are genetic aspects to the processes of development and aging,” said Frank Slack, associate professor of Molecular, Cellular and Developmental Biology and senior author of the paper. “We used the simple, but genetically well-studied, C. elegans worm and found genes that are directly involved in determination of lifespan. Humans have genes that are nearly identical.”

A microRNA and the developmental-timing gene it controls, lin-4 and lin-14, affect patterns of cellular development at very specific stages. Slack’s group found that mutations in these genes alter both the timing of the worm development stages— and the worm lifespan. C. elegans has been the premier model organism for studying the genetics of aging, and an excellent predictor of genes that also control mammalian aging.

To test their functions, they made mutants in both of these genes. Animals with a loss-of-function mutation in lin-4 had a lifespan that was significantly shorter than normal, suggesting that lin-4 prevents premature death. Conversely, over-expressing lin-4 led to a longer lifespan. They also found that a loss–of-function mutation in lin-14, the target of lin-4, caused the opposite effect — a 31 percent longer lifespan.

According to Slack, their results are strong evidence of an “intrinsic biological clock” that runs for aging as well as for normal organ development. Included results showed the developmental programs that these genes regulate are modulated through insulin signaling, demonstrating the connection between insulin-driven metabolism and aging.

The testking offers you incredible self paced training program to help you prepare and pass real exam. Download testking JN0-331 dumps and testking E20-322 study guide to successfully complete your certification.

“This microRNA is conserved in humans leading to the enticing idea of being able to beneficially affect the results of aging including diseases of aging,” said Slack. Work is under way to identify other microRNAs regulators and genes they target, to determine where they function and whether they behave the same way in mice, and to see if they are altered in human diseases of aging.

Source: This story has been adapted from a news release issued by Yale University. Citation: Science: (December 23, 2005)

Advertisements

11 thoughts on “Scientists Discover a Gene That Regulates Lifespan

  1. Pingback: Adjust fake tie, Find a window, Exit through it » Blog Archive » Lifespan gene found

  2. Pingback: Peppermint Sky » Blog Archive » Forgetting to die

  3. Pingback: Peppermint Sky » Blog Archive » Don’t have to be Undead to live forever, maybe.

  4. Pingback: Zen Diaphragm - Biosingularity » Scientists Discover a Gene That Regulates Lifespan

  5. Pingback: the shaky kaiser » Blog Archive » north of easy

  6. Pingback: marjerine.homeip.net » Blog Archive » Scientistists Discover a Gene That Regulates Lifespan

  7. Pingback: Rabbi Yonah’s » Seeing Miracles Everyday

  8. Pingback: General Sciences » Scientistists Discover a Gene That Regulates Lifespan

  9. Daniele Proni

    This is the second gene indentified that reduces aging. Sirt 1,
    2 and 6 are the ones that resveratol activates. Also, resveratrol
    has been shown to increase telemere length.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s