Comments on: Groups of neurons in the brain rewire by changing images http://biosingularity.wordpress.com/2008/03/15/groups-of-neurons-in-the-brain-rewire-by-changing-images/ Advances in biological systems. Mon, 21 Jul 2008 00:51:29 +0000 http://wordpress.org/?v=MU By: Dave http://biosingularity.wordpress.com/2008/03/15/groups-of-neurons-in-the-brain-rewire-by-changing-images/#comment-81507 Dave Sun, 01 Jun 2008 17:59:19 +0000 http://biosingularity.wordpress.com/?p=731#comment-81507 Yes This is interesting me too... Yes This is interesting me too…

]]> By: petryan http://biosingularity.wordpress.com/2008/03/15/groups-of-neurons-in-the-brain-rewire-by-changing-images/#comment-81107 petryan Thu, 27 Mar 2008 14:28:59 +0000 http://biosingularity.wordpress.com/?p=731#comment-81107 This is interesting. I wonder if this can be incorporated into how we think about medications aimed at neurons. I know that older anti-psychotic medications work very well for acutely and floridly psychotic people. Modern anti-psychotics seem to be objectively very poor at treating acute psychosis. This is likely to be due to the mechanisms of action. If the process of psychosis involves the flooding of the brain with Dopamine, perhaps the excess Dopamine is being picked up by Dopamine receptors from dormant neighbouring, neuron dopamine receptors. The old fashioned anti-psychotics block re-uptake, therefore preventing the Dopamine from entering dormant neurons. Modern antipsychotics block the Dopamine to slow the flow of Dopamine into the synapse. If there is already a flooded overload of Dopamine, then their is little immediate benefit to be had from Modern Antipsychotics. Modern anti psychotics probably have a better chance of achieving results in prodromal or mild/emerging psychosis or as a preventative measure in a schizophrenic who is experiencing a remission of symptoms. This is interesting. I wonder if this can be incorporated into how we think about medications aimed at neurons. I know that older anti-psychotic medications work very well for acutely and floridly psychotic people. Modern anti-psychotics seem to be objectively very poor at treating acute psychosis. This is likely to be due to the mechanisms of action.

If the process of psychosis involves the flooding of the brain with Dopamine, perhaps the excess Dopamine is being picked up by Dopamine receptors from dormant neighbouring, neuron dopamine receptors. The old fashioned anti-psychotics block re-uptake, therefore preventing the Dopamine from entering dormant neurons. Modern antipsychotics block the Dopamine to slow the flow of Dopamine into the synapse. If there is already a flooded overload of Dopamine, then their is little immediate benefit to be had from Modern Antipsychotics.

Modern anti psychotics probably have a better chance of achieving results in prodromal or mild/emerging psychosis or as a preventative measure in a schizophrenic who is experiencing a remission of symptoms.

]]> By: morgangreenster http://biosingularity.wordpress.com/2008/03/15/groups-of-neurons-in-the-brain-rewire-by-changing-images/#comment-81021 morgangreenster Mon, 17 Mar 2008 18:29:27 +0000 http://biosingularity.wordpress.com/?p=731#comment-81021 I believe that neural synaptic changes occur when someone effectively deals with very difficult challenges. I believe that neural synaptic changes occur when someone effectively deals with very difficult challenges.

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